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Itolizumab, an investigational anti-CD6 monoclonal antibody, has shown promising results in a phase II clinical trial for patients with moderate to severe ulcerative colitis. Designed to target the CD6-ALCAM pathway, a mechanism implicated in gastrointestinal inflammation, itolizumab was reported to achieve clinical remission rates comparable to adalimumab.
This editorial outlines a clinical approach to patients with periodic inflammation of unknown origin despite initial rational and targeted investigation. The focus of the editorial is on the recognition and diagnosis of systemic autoinflammatory diseases (SAIDs). Although rare, SAIDs are ...
Systemic lupus erythematosus (SLE) is a multisystem, autoimmune disorder affecting skin, joints, kidneys, the heart, lungs, the brain and blood cells, and is characterized by heterogeneous presentations and severity. It is more common in females than males, with a ratio ...
Anti-TNF therapy is a mainstay of treatment for Crohn's disease although treatment failure in patients with IBD is common. touchIMMUNOLOGY were delighted to speak with Simeng Lin (University of Exeter Medical School, Exeter, UK) to discuss the current standard of ...
Fibromyalgia (FM) is defined as widespread musculoskeletal pain and tenderness, in the absence of another explanation. Poor sleep, fatigue and pain are all associated with FM. Diagnostic criteria are well defined,1Â and the prevalence of FM appears to be steadily ...
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