Rheumatoid Arthritis

Roy Fleischmann, ACR 2021: Safety and Efficacy of Tofacitinib vs TNF Inhibitors in ORAL Surveillance

Published Online: November 24th 2021

It was a pleasure to speak with Dr Roy Fleischmann (University of Texas Southwestern Medical Center, Dallas, TX, USA) about ORAL Surveillance (NCT02092467). Mandated by the FDA, due to observed increases in lipids and malignancies in patients with RA treated with tofacitinib, this study was designed to investigate the relative risk of tofacitinib compared to other TNF inhibitors.

The abstract entitled ‘Safety and Efficacy of Tofacitinib vs TNF Inhibitors in RA Patients Aged 50 Years or Older with One or More Cardiovascular Risks: Results from a Phase 3b/4 Randomized Safety Trial’ was presented at the ACR Convergence, 5-9 November 2021.

Questions

  1. Could you tell us about the aims and design of the ORAL Surveillance as well as the findings in terms of MACE, VTEs and malignancies? (0:17)
  2. What are your conclusions from this study? (4:26)
  3. What questions remain unanswered? (5:27)
  4. In brief, what do you think the take-home messages from ORAL surveillance are? (6:45)

Disclosures: Dr Roy Fleischman has acted as a consultant for Pfizer, AbbVie, Eli Lilly, Gilead, GSK, BMS and UCB.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Gina Furnival.

Filmed in coverage of the virtual ACR Convergence 2021.

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