Rheumatoid Arthritis
Watch Time: 6 mins

Vibeke Strand, ACR 2022: Analysis of patient reported outcomes from CREDO 2 and CREDO 3 studies of olokizumab

Published Online: November 22nd 2022

CREDO 2 (NCT02760407) and CREDO 3 (NCT02760433) were phase 3 randomised controlled trials, that investigated the efficacy and safety of olokizumab compared to placebo and adalimumab in moderate to severely active rheumatoid arthritis (RA). touchIMMUNOLOGY were delighted to speak with Prof. Vibeke Strand (Stanford University, Palo Alto, CA, USA) to discuss the findings from her analyses looking at patient reported outcomes (PROs) in these studies and the importance of PROs in clinical trials for RA.

This information is brought to you by Touch Medical Media and is not sponsored by, nor a part of, the American College of Rheumatology.

The abstracts ‘Olokizumab Improves Patient Reported Outcomes in Moderate to Severely Active Rheumatoid Arthritis Patients Inadequately Controlled by Methotrexate (MTX-IR): Results from the Phase III Randomized Controlled Trial.‘ (Abstract number: 0313) and ‘Olokizumab Improved Patient Reported Outcomes in TNF Incomplete Responder (TNF-IR) Rheumatoid Arthritis Patients: Results from the Phase III Randomized Controlled Trial (Abstract number: 0314) were presented at the ACR Convergence, November 10–14, 2022.

Questions

  1. What is the importance of patient reported outcomes in clinical trials in rheumatoid arthritis (RA)? (0:25)
  2. What is the rationale for the use of olokizumab in the treatment of RA? (1:20)
  3. What were the aims, design and eligibility criteria of CREDO 2? (2:01)
  4. What were the findings of the study? (2:48)
  5. Please could you give us an overview of CREDO 3 and the findings from the study? (4:57)
  6. On the basis of these findings and recently published data showing noninferiority to adalimumab in terms of ACR 20, where do you see olokizumab eventually sitting in the treatment paradigm for RA? (5:34)

Disclosures: Vibeke Strand discloses consulting for, serving on advisory boards for and receiving honoraria from Abbvie, Alpine Immune Sciences, Alumis, Amgen Corporation, Aria, AstraZeneca, Bayer, Bioventus, Blackrock, BMS, Boehringer Ingelheim, Celltrion, Chemocentryx, Endo, Equillium, Ermium, Genentech / Roche, Gilead, GSK, Horizon, Inmedix, Janssen, Kiniksa, Kypha, Lilly, Merck, MiMedx, Novartis, Omeros, Pfizer, Priovant, Regeneron, Rheos, R-Pharm, Samsung, Sandoz, Sanofi, Scipher, Setpoint, Sorrento, Spherix, and Tonix.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones.

Filmed in coverage of the ACR Convergence 2022.

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