Home > Xavier Mariette, EULAR 2021: Belimumab plus Rituximab in Primary Sjögren’s Syndrome
Sjögren’s Syndrome

Xavier Mariette, EULAR 2021: Belimumab plus Rituximab in Primary Sjögren’s Syndrome

Published Online: July 2nd 2021

It was a delight to catch up with Professor Xavier Mariette (Université Paris-Saclay and Hôpital Bicêtre, Paris, France) around the phase 2 study investigating subcutaneous belimumab and intravenous rituximab in primary Sjögren’s syndrome.

The abstract ‘SAFETY AND EFFICACY OF SUBCUTANEOUS BELIMUMAB AND INTRAVENOUS RITUXIMAB COMBINATION IN PATIENTS WITH PRIMARY SJÖGREN’S SYNDROME: A PHASE 2, RANDOMISED, PLACEBO-CONTROLLED 68-WEEK STUDY.’ (OP0135) was presented at the European Congress of Rheumatology 2021, 2-5 June 2021.

Questions

  1. What is the rationale for B-cell depletion using belimumab plus rituximab in people with primary Sjögren’s syndrome? (0:15)
  2. Could you tell us a little about the Phase 2 study, its clinical endpoints, and how well the endpoints were met? (1:09)
  3. What will be the next steps in the clinical development of this combination in primary Sjögren’s syndrome? (2:25)

Disclosures: Xavier Mariette discloses honorarium from BMS, GSK, Novartis, Pfizer, Servier, UCB and a research grant from Ose Pharmaceutics.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Victoria Jones.

Filmed as a highlight of EULAR 2021 (Virtual).

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