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  • Psoriasis

    An Introduction to Psoriasis

    Psoriasis is a common, chronic inflammatory skin disease that can also affect the joints. Management involves topical and systemic medication, and phototherapy.  In the past decade, increased understanding of the pathophysiology of autoimmune diseases has resulted in the development of systemic biologic therapies for moderate-to-severe disease, including inhibitors of tumour necrosis factor (TNF) α, and interleukins (IL)-12, IL-23 and IL-17A. Topical medications, including corticosteroids, vitamin D analogues, calcineurin inhibitors and keratolytics, remain the mainstay of treatment of mild-to-moderate disease. Therapies in the pipeline include tapinarof, a topical aryl hydrocarbon receptor modulating agent, and BMS-986165, an oral tyrosine kinase 2 inhibitor.

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    Psoriasis Content

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