Naomi J Patel, ACR 2022: Impact of tocilizumab on HbA1C during giant cell arteritis treatment
GiACTA was a randomized, double-blind, placebo-controlled study that investigated the safety and efficacy of tocilizumab, an IL-6 receptor antagonist, in patients with giant cell arteritis. touchIMMUNOLOGY were delighted to speak with Dr. Naomi J Patel (Massachusetts General Hospital, Boston, MA, USA) to discuss the aims, design and findings from her post-hoc analysis of the GiACTA trial, that looked at the impact of glucocorticoids and tocilizumab on changes in HbA1C over time in those who completed the GiACTA trial.
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The abstract ‘The Effects of Daily Prednisone and Tocilizumab on Hemoglobin A1c During the Treatment of Giant Cell Arteritis.’ (Abstract number: 0461) was presented at the ACR Convergence, November 10–14, 2022.
Questions
- Could you give us a brief overview of the GiACTA trial and its findings? (0:09)
- What were the aims and design of this post-hoc analysis? (0:57)
- What was the impact of tocilizumab on HbA1C? (1:34)
- What was the reason for the observed association between tocilizumab and HbA1C reduction, and what further study is planned? (2:23)
- What are the key take-home messages of this study? (3:12)
Disclosures: Naomi J Patel has nothing to disclose in relation to this video interview.
Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones.
Filmed in coverage of the ACR Convergence 2022.
