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Mehdi Rashighi, EADV 2020 – JAK inhibitors in Vitiligo

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Published Online: Nov 10th 2020

We were delighted to catch up with Mehdi Rashighi (University of Massachusetts Medical School, Boston, MA, USA) to discuss the use of JAK inhibitors in the treatment of vitiligo.

Questions

  1. What are the limitations of current therapeutic approaches for vitiligo? (0:26)
  2. What is the role of the JAK pathway in the pathogenesis of vitiligo? (0:56)
  3. What clinical evidence supports the use of JAK inhibitors in vitiligo? (1:51)
  4. What have been the long-term safety findings of clinical trials to date? (3:00)
  5. Which patients with vitiligo are likely to benefit most from JAK inhibitors and in whom are they contraindicated? (4:40)

Disclosures: In this interview, Mehdi Rashighi discusses unapproved uses of approved products. He was advised by Touch Medical Media to ensure that he disclosed any such references made to unlabelled or unapproved use. No endorsement by Touch Medical Media of any unapproved products or unapproved uses is either made or implied by the mention of these products.

Mehdi Rashighi is the Principal Investigator of studies sponsored by Target RWE and LEO Pharma. He is also Co-Investigator of studies sponsored by Pfizer, Sanofi, Incyte, and Dermavant and serves as an Editorial Board Member of FASEB, Frontiers in Immunology, and VisualDx.

Support: Interview and filming supported by Touch Medical Media.

Filmed in coverage of the EADV 2020 Virtual Congress.

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Thierry Passeron: Efficacy of Ruxolitinib Cream by Body Region in Vitiligo – A Pooled Analysis of the TRuE-V Phase 3 Studies
Watch Time: 4 mins

TRuE-V1 (NCT04052425) and TRuE-V2 (NCT04057573) were randomized, double-blind, vehicle-controlled phase 3 studies investigating ruxolitinib cream in adults and adolescents with vitiligo. touchIMMUNOLOGY were delighted to speak with Prof. Thierry Passeron (University Hospital of Nice, Nice, France) to discuss the rationale and findings from his pooled analysis looking at the effect of ruxolitinib cream on achievement of VASI50 by body region. The abstract 'Effect of Ruxolitinib Cream on Achievement of VASI50 by Body Region: Week 52 Pooled Analysis of the TRuE-V Phase 3 Studies.' (Abstract number: 3640) was presented at EADV 2022, 7-10 September, 2022. Questions Could you give us a brief overview of the clinical development of ruxolitinib cream which has led to its approval for the treatment of vitiligo? (0:11) What have been the efficacy and safety findings of the TRuE-V studies, and how clinically meaningful are these findings? (0:52) What was the rationale for the pooled analysis you are presenting? (1:45) What were the findings of this analysis and what are the implications of these findings? (2:38) What has been the clinical impact of ruxolitinib cream in this indication since its approval? (3:27) Disclosures: Thierry Passeron discloses consulting for Almirall, Abbvie, Amgen, Astellas, BMS, Celgene, Galderma, GSK, Incyte, Isocell, Janssen, LEO Pharma, Lilly, MSD, Novartis, Pfizer, Sanofi-Genzyme, SUN pharma, and UCB pharma; receiving grant/ research support from Abbvie, Almirall, BMS, Celgene, Incyte, Isocell, LEO Pharma, and Lilly; and receiving honoraria from Almirall, Abbvie, Amgen, Astellas, BMS, Celgene, Galderma, GSK, Incyte, Isocell, Janssen, LEO Pharma, Lilly, MSD, Novartis, Pfizer, Sanofi-Genzyme, SUN pharma, and UCB pharma. Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones. This content was developed by Touch Medical Media and is not affiliated with the  European Academy of Dermatology & Venereology  (EADV) or the congress. 

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