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John E Harris, Dermatology Meeting News 2021: Efficacy and Safety of Ruxolitinib in Vitiligo

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Published Online: Jun 14th 2021

We caught up with Prof. John E Harris (University of Massachusetts Medical School, MA, USA) to discuss the safety and efficacy results from a Phase 2 study (NCT03099304) investigating ruxolitinib cream, a JAK1/ JAK2 inhibitor, in adults with vitiligo.

His abstract entitled ‘Safety and Efficacy of Ruxolitinib Cream for the Treatment of Vitiligo: 104-Week Data From a Phase 2 Study‘ was presented at the AAD VMX, 23-25 April 2021.

This information is brought to you by Touch Medical Media and is not sponsored by, nor a part of, the AAD. 

Questions

  1. What is the rationale for the use of ruxolitinib cream in the treatment of adults with vitiligo? (0:05)
  2. What was the design of the Phase 2 study, and what did the primary data analysis teach us? (1:19)
  3. How did the 104-week data compare to that at 52 weeks in terms of the efficacy endpoints? (2:02)
  4. What was the safety profile of treatment with ruxolitinib cream over 104 weeks? (2:40)
  5. What is the clinical significance of these findings? (3:32)

Disclosures: Prof. John E Harris has acted and a consultant and investigator for Pfizer, Genzyme/ Sanofi, Incyte, Rheos Medicines, Sun Pharmaceutical, LEO Pharma, Villaris Therapeutics, Dermavant and TeVido BioDevices; a consultant for AbbVie, Janssen, Almirall, Methuselah Health, Pandion, AnaptysBio, Avita, NIRA Biosciences, Admirx, Granular Therapeutics and Platelet BioGenesis; has Equity in TeVido Biodevices, Rheos, Villaris Therapeutics, NIRA Biosciences and is Founder of Villaris Therapeutics and NIRA Biosciences.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Gina Furnival.

Filmed in coverage of the AAD VMX 2021.

 

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Thierry Passeron: Efficacy of Ruxolitinib Cream by Body Region in Vitiligo – A Pooled Analysis of the TRuE-V Phase 3 Studies
Watch Time: 4 mins

TRuE-V1 (NCT04052425) and TRuE-V2 (NCT04057573) were randomized, double-blind, vehicle-controlled phase 3 studies investigating ruxolitinib cream in adults and adolescents with vitiligo. touchIMMUNOLOGY were delighted to speak with Prof. Thierry Passeron (University Hospital of Nice, Nice, France) to discuss the rationale and findings from his pooled analysis looking at the effect of ruxolitinib cream on achievement of VASI50 by body region. The abstract 'Effect of Ruxolitinib Cream on Achievement of VASI50 by Body Region: Week 52 Pooled Analysis of the TRuE-V Phase 3 Studies.' (Abstract number: 3640) was presented at EADV 2022, 7-10 September, 2022. Questions Could you give us a brief overview of the clinical development of ruxolitinib cream which has led to its approval for the treatment of vitiligo? (0:11) What have been the efficacy and safety findings of the TRuE-V studies, and how clinically meaningful are these findings? (0:52) What was the rationale for the pooled analysis you are presenting? (1:45) What were the findings of this analysis and what are the implications of these findings? (2:38) What has been the clinical impact of ruxolitinib cream in this indication since its approval? (3:27) Disclosures: Thierry Passeron discloses consulting for Almirall, Abbvie, Amgen, Astellas, BMS, Celgene, Galderma, GSK, Incyte, Isocell, Janssen, LEO Pharma, Lilly, MSD, Novartis, Pfizer, Sanofi-Genzyme, SUN pharma, and UCB pharma; receiving grant/ research support from Abbvie, Almirall, BMS, Celgene, Incyte, Isocell, LEO Pharma, and Lilly; and receiving honoraria from Almirall, Abbvie, Amgen, Astellas, BMS, Celgene, Galderma, GSK, Incyte, Isocell, Janssen, LEO Pharma, Lilly, MSD, Novartis, Pfizer, Sanofi-Genzyme, SUN pharma, and UCB pharma. Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones. This content was developed by Touch Medical Media and is not affiliated with the  European Academy of Dermatology & Venereology  (EADV) or the congress. 

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