Axial Spondyloarthritis

Denis Poddubnyy, ACR 2021: Secukinumab and HLA Subtypes in AxSpA

Published Online: November 10th 2021

Prof. Denis Poddubny (Charité-Universitätsmedizin Berlin, Berlin, Germany) kindly took the time to speak with touchIMMUNOLOGY about the post-hoc analysis from the phase 3b SKIPPAIN trial (NCT03136861) aimed at exploring the potential association of HLA-B27 subtypes on the effect of secukinumab in patients with axSpA.

His presentation entitled Efficacy of Secukinumab and HLA-B27 Subtypes: Results from a Phase IIIb Randomised Controlled Trial in Axial SpA(ABSTRACT NUMBER: 0917) was presented at the ACR Convergence, 5-9 November 2021.

Questions

  1. What is known about the association between human leukocyte antigen (HLA) subtypes and axial spondyloarthritis? (0:12)
  2. What were the aims and methodology of this post hoc analysis of the SKIPPAIN trial data? (1:15)
  3. What were the findings of the analysis? (1:40)
  4. What questions remain unanswered about HLA-B27 subtypes and what future studies are planned? (2:17)

Disclosures: Prof. Denis Poddubnyy has received research support from AbbVie, Eli Lilly, MSD, Novartis, and Pfizer; consulting fees from AbbVie, Biocad, Eli Lilly, Gilead, GlaxoSmithKline, Janssen, MSD, Novartis, Pfizer, Samsung Bioepis, and UCB; and speaker fees from AbbVie, Bristol-Myers Squibb, Eli Lilly, MSD, Novartis, Pfizer, and UCB.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Gina Furnival.

Filmed in coverage of virtual ACR Convergence 2021.

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