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    An Introduction to Axial Spondyloarthritis

    Axial spondyloarthritis (axSpA) is an inflammatory disease of the axial skeleton, and causes significant back pain and disability. Treatment involves non-steroidal anti-inflammatory drugs (NSAIDs), physical therapy and exercise. Several anti-tumour necrosis factor (TNF) agents are approved for treatment of radiographic axSpA. Emerging therapeutic targets include interleukin (IL) -17 and the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway. Other emerging treatments include compounds that target IL-17A and IL-17F isoforms and granulocyte macrophage-colony stimulating factor (GM-CSF).  However, many unmet needs remain, including optimising treatment response and biomarkers to identify patients with chronic back pain who may progress to axSpA.

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