An Introduction to Psoriasis
Psoriasis is a common, chronic inflammatory skin disease that can also affect the joints. Management involves topical and systemic medication, and phototherapy. In the past decade, increased understanding of the pathophysiology of autoimmune diseases has resulted in the development of systemic biologic therapies for moderate-to-severe disease, including inhibitors of tumour necrosis factor (TNF) α, and interleukins (IL)-12, IL-23 and IL-17A. Topical medications, including corticosteroids, vitamin D analogues, calcineurin inhibitors and keratolytics, remain the mainstay of treatment of mild-to-moderate disease. Therapies in the pipeline include tapinarof, a topical aryl hydrocarbon receptor modulating agent, and BMS-986165, an oral tyrosine kinase 2 inhibitor.
Browse our selection of video highlights and short articles from the conference hub, which provide insights into the latest updates from major conferences, and a collection of peer-reviewed articles from the journal portfolio. These are complemented by a range of educational activities from our expert faculty, with patient outcomes at the forefront.
Loretta Fiorillo, EADV 2022: Findings from the Phase 3 Study of Apremilast in Paediatric Plaque Psoriasis
Apremilast is an oral small-molecule inhibitor of PDE4 currently approved in adult patients with plaque psoriasis. touchIMMUNOLOGY were delighted to talk with Dr. Loretta Fiorillo (University of Alberta, Edmonton, Canada) to discuss the the aims, design and eligibility criteria of the study investigating apremilast in paediatric patients with moderate to severe plaque psoriasis and how […]
Loretta Fiorillo, EADV 2022: Apremilast Treatment for Plaque Psoriasis in Paediatric Patients
Apremilast is an oral small-molecule inhibitor of PDE4 currently approved in adult patients with plaque psoriasis. It was a pleasure to talk with Dr. Loretta Fiorillo (University of Alberta, Edmonton, Canada) around the unmet needs in the treatment of plaque psoriasis in paediatric patients and the clinical evidence supporting apremilast in this indication. The abstract […]
Linda Stein Gold, EADV 2022: Quality of Life and Clinical Efficacy Findings from PSOARING 1 and PSOARING 2
PSOARING 1 (NCT03956355) and PSOARING 2 (NCT03983980) were two phase 3 trials investigating tapinarof cream, a novel, steroid-free, AhR modulating agent for the treatment of plaque psoriasis. It was a pleasure to speak with Dr Linda Stein Gold (Henry Ford Health System, Detroit, MI, USA) around the aims, design, endpoints and quality of life and […]
Linda Stein Gold, EADV 2022: Tapinarof Cream 1% for the Treatment of Plaque Psoriasis
Tapinarof cream 1% once daily, a topical aryl hydrocarbon receptor (AhR)-modulating agent was recently approved by the FDA for the treatment of plaque psoriasis. touchIMMUNOLOGY were delighted to speak with Dr Linda Stein Gold (Henry Ford Health System, Detroit, MI, USA) to learn more about the unmet needs in the treatment of plaque psoriasis, the rationale […]
Joel M Gelfand, AAD-VMX 2022: Apremilast Impact on Vascular Inflammation and Cardiometabolic Function in Psoriasis
We caught up with Dr. Joel M. Gelfand (Penn Medicine; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA) to discuss the findings from the phase IV study, investigating the impact of apremilast on vascular inflammation and cardiometabolic function when used in the treatment of psoriasis. The abstract ‘A Phase IV, Open Label Study […]
Andrew Blauvelt, AAD-VMX 2022: Malignancy Rates from a 5 Year Follow Up Study of the VOYAGE 1 and 2 Trials
touchIMMUNOLOGY were delighted to talk to Dr. Andrew Blauvelt (Oregon Medical Research Center, Portland, OR, USA) around the 5 year follow up study of the VOYAGE 1 and 2 trials, investigating guselkumab in patients with moderate to severe psoriasis. The abstract ‘Malignancy Rates Through 5 Years of Follow-up in Guselkumab-treated Patients With Moderate to Severe […]
Andy Blauvelt, EADV 2021: Deucravacitinib vs Placebo and Apremilast in Scalp Psoriasis
touchIMMUNOLOGY had the pleasure of speaking with Dr Andy Blauvelt (Oregon Medical Research Center, Portland, OR, USA) about the oral TYK2 inhibitor, deucravacitinib, and how it compared to placebo and apremilast in the treatment of scalp psoriasis. His presentation entitled ‘Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 (TYK2) Inhibitor, Versus Placebo and Apremilast in Scalp […]
Leon Kircik, AAD VMX 2021: Roflumilast Foam in Scalp and Body Psoriasis
Prof. Leon Kircik (Icahn School of Medicine at Mount Sinai, New York, NY, USA) kindly took the time to speak with us about the results from the recent phase 2b study investigating roflumilast foam in the treatment of scalp and body psoriasis. His abstract entitled ‘Once-daily Roflumilast Foam 0.3% for Scalp and Body Psoriasis: A […]
Kim Papp, AAD VMX 2021: Secukinumab PURE Study
We were delighted to discuss with Dr Kim Papp (Probity Medical Research, Waterloo, ON, Canada) results from the PURE study (NCT02786186), designed to investigate the long-term safety profile of secukinumab in patients with moderate to severe chronic plaque psoriasis. The abstract ‘Secukinumab helps achieving clear/almost clear skin and improve quality of life in psoriasis over […]
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