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Digestive Disorders
Watch Time: 5 mins

Jean-Frederic Colombel, ECCO-IBD 2022: Upadacitinib in Ulcerative Colitis: Results from the UPA Phase 3 Programme

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Published Online: Feb 23rd 2022

touchIMMUNOLOGY caught up with Professor Jean-Frederic Colombel (The Mount Sinai Hospital, NY, USA) to discuss the results from the UPA phase 3 programme, investigating the efficacy of upadacitinib on  the extraintestinal manifestations of ulcerative colitis.

The abstract entitled ‘Effect of upadacitinib (UPA) treatment on extraintestinal manifestations (EIMs) in patients with moderate-to-severe Ulcerative Colitis (UC): Results from the UPA Phase 3 programme’ (Presentation no. OP33) was presented at the 17th Congress of ECCO, February 16-19, 2022!

Questions

  1. Could you tell us a little about the extraintestinal manifestations of ulcerative colitis (UC) and their impact on patient quality of life? (0:16)
  2. What have we learned from the U_ACHIEVE and U-ACCOMPLISH studies on the efficacy and safety of upadacitinib in patients with moderate-to-severe UC and what were the findings from the analysis you are presenting? (1:10)
  3. What will be the clinical impact of these findings? (3:09)
  4. Where do you see upadacitinib fitting in the treatment paradigm for UC? (4:03)

Disclosures: Jean-Frederic Colombel reports receiving research grants, payment for lectures and consulting fees from AbbVie.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones.

Filmed in coverage of the ECCO-IBD virtual 2022.

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