Rheumatoid Arthritis

Aurélie Najm, ACR 2021: B-cell Repertoire as a Predictor of Methotrexate Response

Published Online: November 10th 2021

touchIMMUNOLOGY was delighted to speak with Dr Aurélie Najm (University of Glasgow, Glasgow, UK) about B-cell repertoire changes in patients with rheumatoid arthritis and the recent analysis designed to create a nomogram capable of using B-cell repertoire properties to predict response to methotrexate.

The analysis entitled ‘B Cells Repertoire Repartition Predicts Response to Methotrexate at 6 and 12 Months in Naïve RA: A Machine Learning Driven Approach’ (ABSTRACT NUMBER: 0982) was presented at the ACR Convergence, 5-9 November 2021.

Questions

  1. How does the B cell repertoire change in rheumatoid arthritis according to treatment response? (0:19)
  2. Could you tell us a little about the machine learning based approach you have developed for predicting response to methotrexate? (1:02)
  3. What were the aims, design of your study assessing this model? (1:57)
  4. What were the study findings? (2:50)
  5. What will be the potential impact of this approach on clinical practice? (4:02)

Disclosures: Dr Aurélie Najm has acted as a consultant for BMS, UCB and Chugai; and as a speaker for UCB.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Gina Furnival.

Filmed in coverage of virtual ACR Convergence 2021.

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