Inflammatory Bowel Disease

The QUASAR Phase 3 Induction Study (NCT04033445) investigated the efficacy and safety of the IL-23 p19 subunit antagonist guselkumab in the treatment of moderately to severely active ulcerative colitis. We caught up with Dr Jessica Allegretti (Brigham and Women’s Hospital, Boston, MA, USA), to discuss the aims, design and inclusion criteria of the QUASAR Phase […]

Guselkumab is a fully human monoclonal antibody IL-23 p19 subunit antagonist currently being investigated in hard to treat, moderately to severely active ulcerative colitis. We were delighted to speak with Dr Jessica Allegretti, (Brigham and Women’s Hospital, Boston, MA, USA) around the burden of ulcerative colitis in patients with inadequate response to currently approved treatments, […]

 Professor Ailsa Hart (St Mark’s Hospital, London, UK) joined touchIME on World IBD Day and discussed how diagnosis can be challenging, but emerging treatments can improve outcomes for people living with Crohn’s disease or ulcerative colitis. She also highlighted the impact that IBD can have on quality of life, including mental health and the […]

The Personalised Anti-TNF Therapy in Crohn’s disease (PANTS) study was a UK-wide study that looked at anti-TNF treatment failure in Crohn’s disease. touchIMMUNOLOGY were delighted to speak with Simeng Lin (University of Exeter Medical School, Exeter, UK) to discuss the association between DNA methylation and primary non-response to anti-TNF treatment and the impact this will have […]

Anti-TNF therapy is a mainstay of treatment for Crohn’s disease although treatment failure in patients with IBD is common. touchIMMUNOLOGY were delighted to speak with Simeng Lin (University of Exeter Medical School, Exeter, UK) to discuss the current standard of care for Crohn’s disease, anti-TNF therapy and factors thought to predict non-response to anti-TNF treatment. […]

The ELEVATE UC 52 study (NCT03945188) investigated the efficacy and safety of etrasimod in patients with moderately to severely active ulcerative colitis, a recent analysis of the study was presented at ECCO’23 looking at corticosteroid (CS)-free remission as a clinical endpoint. In this touchIMMUNOLOGY interview, we spoke with Dr. Stefan Schreiber (University Hospital Schleswig-Holstein, Kiel, […]

The current treatment paradigm for ulcerative colitis (UC) includes amino salicylic acid as a first line treatment followed by corticosteroids, targeted treatment and rectal topical therapy; however, with corticosteroids (CS) impacting long-term health, CS-free remission has become a long-term goal in treatment. Etrasimod is an S1P receptor modulator, recently investigated for the treatment of UC […]