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    An Introduction to Systemic Lupus Erythematosus

    Systemic lupus erythematosus is a chronic, heterogeneous, multisystem autoimmune disease characterised by severe fatigue and joint pain. Traditional treatment strategies have involved hydroxychloroquine, systemic glucocorticosteroids and conventional immunosuppressive drugs, but are associated with severe toxicities. Many current and emerging therapeutic strategies target B-cell-surface antigen, B-cell survival factors or B-cell intracellular signalling. However, many of these have disappointed in clinical trials, and there remains a need for new strategies. Novel therapies targeting interferons, cytokines and their receptors, intracellular signals, plasma cells, T lymphocytes and co-stimulatory molecules are also being investigated.

    Expert video highlights, insights from the conference hub and comprehensive peer-reviewed articles from our journal portfolio provide updates on the changing treatment landscape. To learn more about how the latest developments impact on patient outcomes view our expert-led learning activities.

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