Systemic Lupus Erythematosus

Susan Manzi, ACR 202: Efficacy of Anifrolumab by Baseline Therapy is SLE

Published Online: November 25th 2021

It was a pleasure to discuss with Dr Susan Manzi (Allegheny Health Network Medicine Institute, Pittsburgh, PA, USA) the recent post-hoc analysis designed to assess the efficacy of anifrolumab by baseline therapy.

The abstract entitled ‘SLE Treatment History and Anifrolumab Efficacy by Baseline Standard Therapies in Patients with SLE from 2 Phase 3 Trials’ was presented at the ACR Convergence, 5-9 November 2021.

Questions

  1. What did the TULIP-1 and TULIP-2 studies teach us about the efficacy and safety of anifrolumab in people with SLE? (0:12)
  2. What were the objectives of the current post-hoc analysis of the TULIP-1 and TULIP-2 data? (0:56)
  3. What were the findings across the different therapy subgroups? (1:35)
  4. Could you tell us a little about the limitations of this study? (2:25)
  5. What are the clinical implications of these findings? (3:07)

Disclosures: Dr Susan Manzi has acted as an advisor for AstraZeneca; a consultant for Exagen Diagnostics, Inc., Cugene, GlaxoSmithKline and Eli Lilly; an officer/board member for the Lupus Foundation of America; received grant/ research support from AstraZeneca, Merck-Serono, AbbVie and GlaxoSmithKline; received royalties from Exagen Diagnostics and has intellectual properties/ patents with Exagen Diagnostics, University of Pittsburgh and the Allegheny Singer Research Institute.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Gina Furnival.

Filmed in coverage of virtual ACR Convergence 2021.

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